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ESR15: (POSITION FILLED) Development of scalable processes for the manufacture of nanocarriers; ChemConnection BV (Oss, The Netherlands)

At ChemConnection, we are passionate about chemistry and (nano)medicines. Our company is dedicated to the development and cGMP manufacture of novel pharmaceutical products comprising complex Active Pharmaceutical Ingredients and nanodelivery systems. Our nanomedicine expertise and capabilities cover the entire process: from building blocks such as monomers, polymers, PEG- and lipid derivatives up to the final nanomedicine pharmaceutical product. ChemConnection’s services range from R&D up to clinical manufacture. Because of our experience and state-of-the art facilities, we have successfully brought tens of compounds from pre-clinical development to commercial reality. This makes ChemConnection one of the leading companies to bring nanomedicine discoveries from all over the world to the clinic.

Early Stage Researcher (PhD Candidate) for the NANOMED European Training Network

within the Marie Sklodowska Curie Programme (1,0 fte)

Application deadline: 23 November 2015

Responsibilities

ChemConnection – based in Oss, The Netherlands – offers a program of training in the field of process development and manufacturing. Our target is to bring newly discovered nanomedicines to clinical trials, by adapting laboratory preparation protocols for large scale cGMP production. At the same time, we develop and implement analytical methods to perform the required quality control of intermediates and products. ChemConnection is cGMP certified by the Dutch Health Authorities (IGZ) and has licenses for GMP manufacture of Active Pharmaceutical Ingredients (API), and bulk nanoparticles, and for testing of API, bulk nanoparticles, and formulations. The company is a rapidly growing organization, which creates a dynamic and supportive work environment. Close collaboration with the Prof.dr. Jan van Hest Bio-Organic Chemistry research group at Radboud University – based in Nijmegen, the Netherlands – guarantees the academic nature of the program.

The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. Besides your appointment at ChemConnection, you will be enrolled in Radboud University’s doctoral program. You will defend your PhD at the end of the project at Radboud University. The PhD research in the Netherlands will be conducted in English.

Early Stage Researcher (ESR) 15: Development of scalable processes for the manufacture of nanomedicines

In this ESR-task, robust and scalable processes will be developed for various building blocks and functionalized nanoparticles. This includes the required analytical method development to characterize the products, and to monitor the effects of scale up on the product quality and the consistency of the manufacturing processes. Both batch and flow processes may be evaluated for each product. The manufacturing process of the nanocarriers entails not only the preparation of the particles but also the purification of the particles for which various scalable methods can be applied. During the purification steps all solvent residues, free polymer residues, free API residues, and other residues need to be removed in order to obtain a product that can in principle be tested in preclinical and clinical studies. The investigation of the processes will therefore also take into account quality requirements of EMA and FDA as described in guidances for pharmaceutical nanomedicine development. The aim is to set up manufacturing processes that could be readily translated into GMP manufacturing of clinical products.

Skills required: supramolecular chemistry, nanoscience, hands-on experience with organic chemistry, analysis techniques, affinity with pharmaceutical development.

Work environment

You will perform your PhD research in a multidisciplinary Initial Training Network (ITN) project called NANOMED.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree; You have excellent communication skills and are able to work efficiently in a team. Specific technical requirements are mentioned separately for the individual ESR descriptions. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in the Netherlands for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays such as holidays are not taken into account).

What we have to offer

  • employment: 1,0 fte;
  • duration of the contract: 3 years;
  • the gross salary amounts to € 2497 per month in the first year, € 2562 per month in the second year, and € 2627 per month in the third year on the basis of a 40 h work week;
  • in addition to the salary: an 8 % holiday allowance, and participation in the pension scheme of ChemConnection.

Would you like to know more?

Are you interested?

Email your application to the human resource department of ChemConnection exclusively: hr@chemconnection.nl. Your application should include (and be limited to) the following attachments:

  • Letter of motivation;
  • Curriculum Vitae.

For more information on your application: hr@chemconnection.nl

No commercial propositions please.

ESR14: (POSITION FILLED) Polycationic amphiphilic cyclodextrins (CDs) for intraperitoneal siRNA/PXT delivery; Ghent University (Belgium)

The university of Ghent (UG) is a top 100 university counting over 41000 students and 9000 employees. UG aims to encourage its students to adopt a critical attitude within a creative, development-oriented educational and research environment. UG is composed of 11 faculties and more than 117 faculty departments. In addition to these faculties, UG has 5 doctoral schools, which provide support to doctoral students through specialized courses as well as transferable skills training, contribute to a quality culture in research, and take care of the social and international visibility of the doctoral degree.

The following vacancy is available at UG, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, Laboratory of General Biochemistry and Physical Pharmacy (LGBPP).

Early Stage Researcher (PhD Candidate) for the NANOMED Innovative Training Network within the Marie Sklodowska Curie Programme (1,0 fte)

Application deadline: 1 January 2016

The LGBPP, hosting both the Ghent Research Group on Nanomedicines (GRGN) and the Bio-photonic Imaging Group (BPIG), mainly performs pre-clinical research in the field of micro-and nanomaterials for biomedical applications. GRGN is largely involved in the design and evaluation of novel micro-and nanomaterials for drug delivery, therapy and diagnostics, whereas research of the BPIG is focused on the development of biophotonic methodologies for biomedical applications. More specifically, a major focus in the LGBPP is the development of novel strategies to improve delivery of nucleic acid therapeutics (siRNA, miRNA, mRNA, pDNA), representing a class of molecules which are not yet in clinical use though under intensive scrutiny for therapeutic applications. Besides on the design of such delivery materials (e.g. nanomedicines), LGBPP aims to unravel their biophysical behavior following administration, both in relevant extracellular fluids (e.g. full blood, lung sputa, gastric fluids, intraperitoneal fluids,…) as well as in the intracellular environment. To this end,  the Ghent Group has developed a unique expertise in the application of advanced microscopy methods to measure nanoparticle stability in all sorts of biological fluids. In the coming years, exploring the delivery potential of nanomedicines for biotechnological drugs will remain the major research theme of our group. Therapeutic emphasis will be placed on (i) pulmonary delivery of nanomedicines (inflammatory/infectious diseases of the lung), (ii) intravitreal delivery of nanomedicines (retinal diseases), (iii) intraperitoneal administration of nanomedicines (cancer) and (iv) cancer immunotherapy. The LGBPP is an international and multidisciplinairy research group, containing about 30 persons and has many collaborations with academic groups worldwide.

The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. You will be enrolled in the Doctoral School of Live Sciences of UG and will defend your PhD at the end of the project. The PhD research will be conducted in English.

Early Stage Researcher 14: cyclodextrines for combined delivery of siRNA and chemotherapeutics to the peritoneal cavity

The task of the ESR is to develop and evaluate a series of cyclodextrin formulations for the combined encapsulation and administration of hydrophilic siRNA and hydrophobic chemotherapeutics to the peritoneal cavity. In order to prevent aggregation, different degrees of surface functionalization with PEG-chains should be evaluated. High encapsulation efficiency of siRNA and PXT should be obtained, with little to no premature siRNA release in biological extracellular fluids such as blood and intraperitoneal fluids. Biological activity, colloidal stability, toxicity and in vivo biodistribution of selected cyclodextrin formulations will be evaluated. Cyclodextrines with good in vitro stability in biofluids will be tested in animal models with induced peritoneal carcinomatosis by SKOV-3 cells expressing firefly luciferase. CDs will be injected intraperitoneally and their in vivo stability will be evaluated as a function of time by performing advanced microscopy techniques on samples taken from the IP fluid and the blood. Ideally, CDs should not aggregate and remain in the peritoneum for a sufficiently long time. The biological activity of the CDs will be assessed by following tumor growth and downregulation of firefly luciferase.

Work environment

You will perform your PhD research in a multidisciplinary Innovative Training Network (ITN) project called NANOMED.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree. You have excellent communication skills and are able to work efficiently in a team. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in Belgium for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays such as holidays are not taken into account).

What we have to offer

  • employment: 1,0 fte;
  • tax free fellowship including full social security coverage (net monthly amount starting at ± 1.900 EUR/month plus end-of-year and vacation allowance), mobility allowance  and (if applicable) family allowance
  • duration of the contract: 3 years

Would you like to know more?

  • Further information on the NANOMED project: nanomeditn.eu
  • Further information on the research group: biofys.ugent.be
  • For more information about this vacancy, please contact: Prof. Dr. Katrien Remaut (katrien.remaut@ugent.be)

Are you interested?

Please send your application to Prof. Remaut (katrien.remaut@ugent.be). Your application should include (and be limited to) the following attachments:

  • Letter of motivation
  • Curriculum Vitae

No commercial proposition please

ESR13: (POSITION FILLED) Biodistribution of Nanomedicine Libraries; University of Helsinki (Finland)

At University of Helsinki, we perform research and educate students covering the full width of the academic spectrum. Our campus is located in Viikki on a green, modern campus with state-of-the-art facilities that include pharmaceutical sciences, biotechnology, neuroscience, veterinary medicine, and biosciences. University of Helsinki is internationally recognized member university in LERU (League of European Research Universities.

The Faculty of Pharmacy at the University of Helsinki invites applications for the NANOMED European Training Network within Marie Sklodowska Curie Programme. The applications are invited for a

DOCTORAL STUDENT POSITION (Early Stage Researcher 13: Biodistribution of Nanomedicine Libraries)

In this ESR project, nanomedicine libraries will be generated with unique marker molecule in each particle type. The analyses of nanoparticle will be carried out using LC/MS methods. The interactions of the nanoparticles with ocular cells and tissues and tissue distribution in vivo will be investigated. Selected particles will be tested for pharmacological activity against choroidal neovascularization in the animal eyes. The experimental data will be integrated into a pharmacokinetic model.

Required background: M.Sc. degree in appropriate field of science (e.g. pharmacy, chemistry, chemical engineering, biology, biotechnology).

Prof. Arto Urtti’s multi-disciplinary research group at University of Helsinki, Faculty of Pharmacy, in Finland, offers a training programme in the field of biopharmaceutical sciences. The group’s target is to build materials for targeted and controlled drug delivery. Research activity involves physico-chemical aspects of the materials and formulations, biological features of drug delivery systems in the cells and tissues, and computational simulation methods to model drug delivery processes in the body. The group has particularly strong expertise in ocular drug delivery and related pharmacokinetics. The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. You will be enrolled in University of Helsinki doctoral programme in drug reserch and will defend your PhD at the end of the project. The PhD research in the Helsinki will be conducted in English. You will perform your PhD research in a multidisciplinary Initial Training Network (ITN) project called NANOMED.

What we have to offer

  • Employment: 1,0 fte;
  • Duration of the contract: 4 years;
  • The University of Helsinki offers a salary dependent on qualifications and work experience. The salary will be based on levels 2-4 of the job requirement scheme for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee shall be paid a salary component based on personal work performance. At the beginning of the employment period a doctoral student’s salary will range from €2100 to €2700 gross per month;
  • All standard pension benefits and occupational health care are provided for university employees.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree. You have excellent communication skills and are able to work efficiently in a team. Specific technical requirements are mentioned separately for the individual ESR descriptions. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in Finland for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays, such as holidays, are not taken into account).

Would you like to know more?

Are you interested?

Your application should include (and be limited to) the following attachments:

  • Letter of motivation;
  • Curriculum Vitae.

Please submit your application, together with the required attachments, through the University of Helsinki Recruitment System via the link Apply for job (https://www.helsinki.fi/en/open-positions). The dead line for applications is 23rd November 2015.

ESR12: (POSITION FILLED) Retinal drug delivery with nanomedicines; University of Helsinki (Finland)

At University of Helsinki, we perform research and educate students covering the full width of the academic spectrum. Our campus is located in Viikki on a green, modern campus with state-of-the-art facilities that include pharmaceutical sciences, biotechnology, neuroscience, veterinary medicine, and biosciences. University of Helsinki is internationally recognized member university in LERU (League of European Research Universities).

The Faculty of Pharmacy at the University of Helsinki invites applications for the NANOMED European Training Network within Marie Sklodowska Curie Programme. The applications are invited for a

DOCTORAL STUDENT POSITION (Early Stage Researcher 12: Retinal drug delivery with nanomedicines)

In this ESR project, nanomedicines will be investigated in biological context to generate data towards improved ocular drug delivery. Nanoparticles will be formulated, characterized, and their interactions with isolated eye tissues will be studied. The cellular uptake, intracellular kinetics and anti-neovascular effects of the nanomedicines will be investigated with cultured ocular cells. The last parts of the Ph.D. thesis include analyses of tissue distribution and pharmacological anti-neovascular effects of the nanomedicines in laboratory animals. These in vivo experiments utilize advanced imaging methods and the experimental data will be integrated into a computational PK/PD model.

Required background: M.Sc. degree in appropriate field of science (e.g. pharmacy, medicine, chemistry, biology).

Prof. Arto Urtti’s multi-disciplinary research group at University of Helsinki, Faculty of Pharmacy, in Finland, offers a training programme in the field of biopharmaceutical sciences. The group’s target is to build materials for targeted and controlled drug delivery. Research activity involves physico-chemical aspects of the materials and formulations, biological features of drug delivery systems in the cells and tissues, and computational simulation methods to model drug delivery processes in the body. The group has particularly strong expertise in ocular drug delivery and related pharmacokinetics. The NANOMED network will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and inter-sectoral experience. You will be enrolled in University of Helsinki doctoral programme in drug research and will defend your PhD at the end of the project. The PhD research in Helsinki will be conducted in English. You will perform your PhD research in a multidisciplinary Initial Training Network (ITN) project called NANOMED.

What we have to offer

  • Employment: 1,0 fte;
  • Duration of the contract: 4 years;
  • The University of Helsinki offers a salary dependent on qualifications and work experience. The salary will be based on levels 2-4 of the job requirement scheme for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee shall be paid a salary component based on personal work performance. At the beginning of the employment period a doctoral student’s salary will range from €2100 to €2700 gross per month;
  • All standard pension benefits and occupational health care are provided for university employees.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree. You have excellent communication skills and are able to work efficiently in a team. Specific technical requirements are mentioned separately for the individual ESR descriptions. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in Finland for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays, such as holidays, are not taken into account).

Would you like to know more?

  • Further information on: The NANOMED project;
  • Further information on: Drug Delivery group (http://www.cdr.fi/);
  • For more information about this vacancy, please contact:
    • Prof. Arto Urtti;
    • E-mail: arto.urtti@helsinki.fi.

Are you interested?

Your application should include (and be limited to) the following attachments:

  • Letter of motivation;
  • Curriculum Vitae.

Please submit your application, together with the required attachments, through the University of Helsinki Recruitment System via the link Apply for job (https://www.helsinki.fi/en/open-positions). The deadline for applications is 23rd November 2015.

ESR11: (POSITION FILLED) Materials-based Characterisation of Innovative Nanomaterials; Imperial College London (UK)

The Department of Materials at Imperial College London wishes to appoint a postgraduate “early-stage researcher” funded by “Nanomed” (H2020-MSCA-ITN-2015), a Marie Skłowdowska-Curie European Training Network. The successful applicant will carry out a three-year programme of research comprising PhD studies. This post is based within the Biomaterials group at Imperial College London, working under the supervision of Professor Molly Stevens. The Stevens group has received numerous awards for outstanding biomaterials related research and comprises a very international and multidisciplinary group of Research Fellows and PhD students.

The training network is made up of 7 partners and 5 partner organizations, coordinated by the Radboud University in Nijmegen, the Netherlands. The network will recruit a total of 15 postgraduates for project work lasting for 36 months, two of whom will be based at Imperial College London. You will be offered extensive opportunities for collaborative work, both within and external to Imperial College.

The Nanomed consortium is designing and evaluating innovative nanocarriers for therapeutic applications and those in regenerative medicine. This subproject aims to fully characterize these systems in the presence of cells using materials-based characterization techniques such as live-cell Raman micro-spectroscopy. The information and insight provided will create a feedback loop for the consortium for the development of optimal nanocarrier designs.

The funding source requires candidates to have not been resident in the UK for more than 12 months in the past three years, to be in the first four years of their research careers and not in possession of a PhD. Candidates are expected to hold (or to be about to receive) a Master’s degree (or equivalent) in Physics, Engineering, Materials Science or Engineering or equivalent, at a level comparable with a UK First Class or Distinction. Knowledge of chemical synthetic protocols and materials science is highly desirable. Candidates must be able to work in an internationally-oriented environment, including fluency in English.

Would you like to know more?

Our preferred method of application is online via our website at the following link: job applicants (select “Job Search” and enter the job reference no EN20150339FH). Please complete and upload an application form as directed and submit any other relevant supporting documents such as your full CV.

Further information can be obtained from Professor Molly Stevens, m.stevens@imperial.ac.uk

Should you have any queries about the application process please contact: Mrs Darakshan Khan, d.khan@imperial.ac.uk

Imperial Managers lead by example. Committed to equality and valuing diversity. We are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Two Ticks Employer and are working in partnership with GIRES to promote respect for trans people.

MSCA-ITN eligibility criteria

There are strict eligibility requirements for the ESR PhD positions in MSCA-ITN. Please ensure that you qualify before applying, as ineligible candidates cannot be considered.

  • Applicants should not have resided or performed their main activity (work, studies, etc) in the country of the host institution for more than 12 months in the 3 year period immediately prior to the start date of the PhD research.
  • Applicants for the ESR PhD positions should be in the first 4 years (full-time equivalent) of their research careers and not yet have been awarded a doctorate. This 4 year period is measured from the date of obtaining the degree which would formally entitle to embark on a doctorate.

MSCA-ITN offers an attractive salary and working conditions. An unique feature of MSCA-ITN is that during the PhD research, ESR PhD students will be given the opportunity to perform at least two secondments of about 3 months each at the facilities of other consortium members. ESR PhD students will benefit from a dedicated training program in the various fields of expertise of the consortium partners. Salary is complemented with a mobility allowance.

For more information on MSCA-ITN, visit Research & Innovation; Marie Sklodowska-Curie actions

ESR10: (POSITION FILLED) Biochemical Characterisation of the Intracellular Uptake of Nanomaterials; Imperial College London (UK)

The Department of Materials at Imperial College London wishes to appoint a postgraduate “early-stage researcher” funded by “Nanomed” (H2020-MSCA-ITN-2015), a Marie Skłowdowska-Curie European Training Network. The successful applicant will carry out a three-year programme of research comprising PhD studies. This post is based within the Biomaterials group at Imperial College London, working under the supervision of Professor Molly Stevens. The Stevens group has received numerous awards for outstanding biomaterials related research and comprises a very international and multidisciplinary group of Research Fellows and PhD students.

The training network is made up of 7 partners and 5 partner organizations, coordinated by the Radboud University in Nijmegen, the Netherlands. The network will recruit a total of 15 postgraduates for project work lasting for 36 months, two of whom will be based at Imperial College London. You will be offered extensive opportunities for collaborative work, both within and external to Imperial College.

The Nanomed consortium is designing and evaluating innovative nanocarriers for therapeutic applications and those in regenerative medicine. This subproject aims to fully characterize these systems in the presence of cells using biochemical assays to elucidate the mechanisms of intracellular uptake. This knowledge will elucidate the potential of the nanocarriers and identify the optimal candidate(s) for their further development, optimization or pre-clinical evaluation.

The funding source requires candidates to have not been resident in the UK for more than 12 months in the past three years, to be in the first four years of their research careers and not in possession of a PhD. Candidates are expected to hold (or to be about to receive) a Master’s degree (or equivalent) in Biology, Biomedical Engineering or equivalent, at a level comparable with a UK First Class or Distinction. Knowledge of chemical synthetic protocols and materials science is highly desirable. Candidates must be able to work in an internationally-oriented environment, including fluency in English.

Would you like to know more?

Our preferred method of application is online via our website at the following link: job applicants (select “Job Search” and enter the job reference no EN20150341FH). Please complete and upload an application form as directed and submit any other relevant supporting documents such as your full CV.

Further information can be obtained from Professor Molly Stevens, m.stevens@imperial.ac.uk

Should you have any queries about the application process please contact: Mrs Darakshan Khan, d.khan@imperial.ac.uk

Imperial Managers lead by example. Committed to equality and valuing diversity. We are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Two Ticks Employer and are working in partnership with GIRES to promote respect for trans people.

MSCA-ITN eligibility criteria

There are strict eligibility requirements for the ESR PhD positions in MSCA-ITN. Please ensure that you qualify before applying, as ineligible candidates cannot be considered.

  • Applicants should not have resided or performed their main activity (work, studies, etc) in the country of the host institution for more than 12 months in the 3 year period immediately prior to the start date of the PhD research.
  • Applicants for the ESR PhD positions should be in the first 4 years (full-time equivalent) of their research careers and not yet have been awarded a doctorate. This 4 year period is measured from the date of obtaining the degree which would formally entitle to embark on a doctorate.

MSCA-ITN offers an attractive salary and working conditions. An unique feature of MSCA-ITN is that during the PhD research, ESR PhD students will be given the opportunity to perform at least two secondments of about 3 months each at the facilities of other consortium members. ESR PhD students will benefit from a dedicated training program in the various fields of expertise of the consortium partners. Salary is complemented with a mobility allowance.

For more information on MSCA-ITN, visit Research & Innovation; Marie Sklodowska-Curie actions

ESR9: (POSITION FILLED) Colloidal stable liposomal formulations for in vivo siRNA delivery; Ghent University (Belgium)

The university of Ghent (UG) is a top 100 university counting over 41000 students and 9000 employees. UG aims to encourage its students to adopt a critical attitude within a creative, development-oriented educational and research environment. UG is composed of 11 faculties and more than 117 faculty departments. In addition to these faculties, UG has 5 doctoral schools, which provide support to doctoral students through specialized courses as well as transferable skills training, contribute to a quality culture in research, and take care of the social and international visibility of the doctoral degree.

The following vacancy is available at UG, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, Laboratory of General Biochemistry and Physical Pharmacy (LGBPP).

Early Stage Researcher (PhD Candidate) for the NANOMED Innovative Training Network within the Marie Sklodowska Curie Programme (1,0 fte)

Application deadline: 1 January 2016

The LGBPP, hosting both the Ghent Research Group on Nanomedicines (GRGN) and the Bio-photonic Imaging Group (BPIG), mainly performs pre-clinical research in the field of micro-and nanomaterials for biomedical applications. GRGN is largely involved in the design and evaluation of novel micro-and nanomaterials for drug delivery, therapy and diagnostics, whereas research of the BPIG is focused on the development of biophotonic methodologies for biomedical applications. More specifically, a major focus in the LGBPP is the development of novel strategies to improve delivery of nucleic acid therapeutics (siRNA, miRNA, mRNA, pDNA), representing a class of molecules which are not yet in clinical use though under intensive scrutiny for therapeutic applications. Besides on the design of such delivery materials (e.g. nanomedicines), LGBPP aims to unravel their biophysical behavior following administration, both in relevant extracellular fluids (e.g. full blood, lung sputa, gastric fluids, intraperitoneal fluids,…) as well as in the intracellular environment. To this end,  the Ghent Group has developed a unique expertise in the application of advanced microscopy methods to measure nanoparticle stability in all sorts of biological fluids. In the coming years, exploring the delivery potential of nanomedicines for biotechnological drugs will remain the major research theme of our group. Therapeutic emphasis will be placed on (i) pulmonary delivery of nanomedicines (inflammatory/infectious diseases of the lung), (ii) intravitreal delivery of nanomedicines (retinal diseases), (iii) intraperitoneal administration of nanomedicines (cancer) and (iv) cancer immunotherapy. The LGBPP is an international and multidisciplinairy research group, containing about 30 persons and has many collaborations with academic groups worldwide.

The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. You will be enrolled in the Doctoral School of Live Sciences of UG and will defend your PhD at the end of the project. The PhD research will be conducted in English.

Early Stage Researcher 9: Colloidal stable liposomal formulations for in vivo siRNA delivery

The task of the ESR is to develop a series of liposomal formulations for in vivo siRNA delivery. In order to prevent aggregation, different types of PEGylated lipids will be evaluated. Different encapsulation methods will be explored to ensure high encapsulation efficiency of siRNA, with little to no premature siRNA release in biological extracellular fluids such as blood and intraperitoneal fluids. Biological activity, colloidal stability, tumor penetration, toxicity and in vivo biodistribution of selected liposomal formulations will be evaluated. The final goal of this project is to optimally design non-viral nucleic acid delivery systems through a better understanding of how their physicochemical properties correlate with the obtained biological activity. Initially, the biological activity (downregulation in the case of siRNA) will be evaluated in vitro on the human ovarian SKOV-3 cancer cell line. Then, the complexes will be evaluated in the in vivo situation, by using mice that were injected with tumor forming SKOV-3 cells to induce peritoneal metastases. Subsequently, the effect of siRNA complexes delivered via the IP or IV route of administration will be evaluated and compared with the anti-tumor effect obtained with conventional IV or IP chemotherapy.

Work environment

You will perform your PhD research in a multidisciplinary Innovative Training Network (ITN) project called NANOMED.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree. You have excellent communication skills and are able to work efficiently in a team. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in Belgium for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays such as holidays are not taken into account).

What we have to offer

  • employment: 1,0 fte;
  • tax free fellowship including full social security coverage (net monthly amount starting at ± 1.900 EUR/month plus end-of-year and vacation allowance), mobility allowance  and (if applicable) family allowance
  • duration of the contract: 3 years

Would you like to know more?

  • Further information on the NANOMED project: nanomeditn.eu
  • Further information on the research group: biofys.ugent.be
  • For more information about this vacancy, please contact: Prof. Dr. Katrien Remaut (katrien.remaut@ugent.be)

Are you interested?

Please send your application to Prof. Remaut (katrien.remaut@ugent.be). Your application should include (and be limited to) the following attachments:

  • Letter of motivation
  • Curriculum Vitae

No commercial proposition please.

ESR8: (POSITION FILLED) Colloidaly stable nanogel formulations for pulmonary siRNA delivery; Ghent University (Belgium)

The university of Ghent (UG) is a top 100 university counting over 41000 students and 9000 employees. UG aims to encourage its students to adopt a critical attitude within a creative, development-oriented educational and research environment. UG is composed of 11 faculties and more than 117 faculty departments. In addition to these faculties, UG has 5 doctoral schools, which provide support to doctoral students through specialized courses as well as transferable skills training, contribute to a quality culture in research, and take care of the social and international visibility of the doctoral degree. The following vacancy is available at UG, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, Laboratory of General Biochemistry and Physical Pharmacy (LGBPP).

Early Stage Researcher (PhD Candidate) for the NANOMED Innovative Training Network within the Marie Sklodowska Curie Programme (1,0 fte)

Application deadline: 1 January 2016

The LGBPP, hosting both the Ghent Research Group on Nanomedicines (GRGN) and the Bio-photonic Imaging Group (BPIG), mainly performs pre-clinical research in the field of micro-and nanomaterials for biomedical applications. GRGN is largely involved in the design and evaluation of novel micro-and nanomaterials for drug delivery, therapy and diagnostics, whereas research of the BPIG is focused on the development of biophotonic methodologies for biomedical applications. More specifically, a major focus in the LGBPP is the development of novel strategies to improve delivery of nucleic acid therapeutics (siRNA, miRNA, mRNA, pDNA), representing a class of molecules which are not yet in clinical use though under intensive scrutiny for therapeutic applications. Besides on the design of such delivery materials (e.g. nanomedicines), LGBPP aims to unravel their biophysical behavior following administration, both in relevant extracellular fluids (e.g. full blood, lung sputa, gastric fluids, intraperitoneal fluids,…) as well as in the intracellular environment. To this end,  the Ghent Group has developed a unique expertise in the application of advanced microscopy methods to measure nanoparticle stability in all sorts of biological fluids. In the coming years, exploring the delivery potential of nanomedicines for biotechnological drugs will remain the major research theme of our group. Therapeutic emphasis will be placed on (i) pulmonary delivery of nanomedicines (inflammatory/infectious diseases of the lung), (ii) intravitreal delivery of nanomedicines (retinal diseases), (iii) intraperitoneal administration of nanomedicines (cancer) and (iv) cancer immunotherapy. The LGBPP is an international and multidisciplinairy research group, containing about 30 persons and has many collaborations with academic groups worldwide.

The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. You will be enrolled in the Doctoral School of Live Sciences of UG and will defend your PhD at the end of the project. The PhD research will be conducted in English.

Early Stage Researcher 8: Colloidally stable nanogel formulations for pulmonary siRNA delivery

The global objective of this research project is to evaluate the nanogel carrier platform for efficient delivery of siRNA into lung-related cell types. Initial emphasis will be placed on the optimization of the nanogel preparation protocol, with ample attention for scale-up, translation to GMP workflow, lyophilisation to ensure long-term stability, and preparation of lipid-coated nanogel hybrids. The nanoparticle composition (both the nanogel core and the lipid coat) will be tailored to merge both cytocompatibility and optimal siRNA delivery performance. The colloidal stability of siRNA-loaded nanogels and possible premature siRNA release will be investigated in vitro in selected pulmonary secretions as well as in serum and ex vivo following inhalation therapy in mice and bronchoalveolar lavage. To this end, in-house developed advanced fluorescence microscopy methods will be applied. Finally, biodistribution, (immuno)toxicity and siRNA delivery will be evaluated in vivo in relevant mouse models.

Work environment

You will perform your PhD research in a multidisciplinary Innovative Training Network (ITN) project called NANOMED.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree. You have excellent communication skills and are able to work efficiently in a team. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in Belgium for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays such as holidays are not taken into account).

What we have to offer

  • employment: 1,0 fte;
  • tax free fellowship including full social security coverage (net monthly amount starting at ± 1.900 EUR/month plus end-of-year and vacation allowance), mobility allowance  and (if applicable) family allowance
  • duration of the contract: 3 years

Would you like to know more?

  • Further information on the NANOMED project: nanomeditn.eu
  • Further information on the research group: biofys.ugent.be
  • For more information about this vacancy, please contact: Prof. Dr. Stefaan De Smedt (stefaan.desmedt@ugent.be)

Are you interested?

Please send your application to Prof. De Smedt (stefaan.desmedt@ugent.be). Your application should include (and be limited to) the following attachments:

  • Letter of motivation
  • Curriculum Vitae

No commercial proposition please.

ESR7 (POSITION FILLED): Small-sized polymeric micelles for targeted drug delivery; Utrecht University (The Netherlands)

Utrecht University has great ambitions for its teaching quality and study success rates. This also applies to its clear research profiles which are centered around four themes: Sustainability, Life Sciences, Youth & Identity, and Institutions. Utrecht University plays a prominent role in our society and contributes to finding the answers to topical and future societal issues.

The Faculty of Science consists of six departments: Biology, Pharmaceutical Sciences, Information and Computing Sciences, Physics and Astronomy, Chemistry and Mathematics. The Faculty is home to 3500 students and nearly 2000 staff and is internationally renowned for the quality of its research. The Faculty’s academic programmes reflect developments in today’s society.

Early Stage Researcher (PhD Candidate) for the NANOMED European Training Network

within the Marie Sklodowska Curie Programme (1,0 fte)

Application deadline: 18 November 2015 (Closed, position is filled)

Responsibilities

The core activity of the Pharmaceutics group is the design and pre-clinical testing of tailor-made drug delivery systems for site-specific, time- and/or rate-controlled delivery of small molecular weight drugs, therapeutic proteins, and nucleic acids (including DNA and siRNA). The major strength of the department is the multidisciplinary nature. As such it can cover the development of drug delivery systems from the design and synthesis up to preclinical testing. It has a good infrastructure for synthesis and characterization of nanoparticles in addition to a dedicated cell culture facility. In addition, it has access to one of the biggest laboratory animal facilities in Europe providing support in animal testing and in vivo imaging. The dept. Pharmaceutics is a member of the faculty of Science, but is also part of the Utrecht Life Science Cluster with the aim to advance therapies into the clinic. In addition, the dept. Pharmaceutics has many collaborations with academic groups and biopharmaceutical companies worldwide.

The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. You will be enrolled in the Graduate School of Life Sciences of Utrecht University and will defend your PhD at the end of the project. The PhD research in the Netherlands will be conducted in English.

Early Stage Researcher 7: Small-sized polymeric micelles for targeted drug delivery

The task of the ESR is to rationally design and synthesize pH-sensitive, amphiphilic block copolymers that can form small-sized micelles suitable for delivery of small molecule drugs. These polymeric micelles will be fully characterized in terms of colloidal stability, drug loading capacity and targeted delivery of anticancer drugs to tumors.

Skills required: basic organic chemistry, polymer chemistry, nanoscience, NMR spectroscopy, separation techniques

Work environment

You will perform your PhD research in a multidisciplinary Initial Training Network (ITN) project called NANOMED.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree; You have excellent communication skills and are able to work efficiently in a team. Specific technical requirements are mentioned separately for the individual ESR descriptions. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in the Netherlands for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays such as holidays are not taken into account).

What we have to offer

  • employment: 1,0 fte;
  • the gross starting salary amounts to € 2,125 per month, and will increase to € 2,717 in the fourth year;
  • in addition to the salary: an 8 % holiday allowance and an 8.3 % end-of-year bonus;
  • duration of the contract: 4 years;
  • you will be classified as a PhD candidate in the Dutch university job-ranking system (UFO).

Are you interested in our excellent employment conditions?

Would you like to know more?

Are you interested?

You should upload your application exclusively using the button ‘Apply’ on the relevant vacancy on the UU vacancy website. Your application should include (and be limited to) the following attachments:

  • Letter of motivation
  • Curriculum VitaeNo commercial propositions please.
  • For more information on your application: +31 (0)30 2536964

ESR6: (POSITION FILLED) Self-assembling peptides as scaffolds for mixed DNA/peptide vaccines; Utrecht University (The Netherlands)

Utrecht University has great ambitions for its teaching quality and study success rates. This also applies to its clear research profiles which are centered around four themes: Sustainability, Life Sciences, Youth & Identity, and Institutions. Utrecht University plays a prominent role in our society and contributes to finding the answers to topical and future societal issues.

The Faculty of Science consists of six departments: Biology, Pharmaceutical Sciences, Information and Computing Sciences, Physics and Astronomy, Chemistry and Mathematics. The Faculty is home to 3500 students and nearly 2000 staff and is internationally renowned for the quality of its research. The Faculty’s academic programmes reflect developments in today’s society.

Early Stage Researcher (PhD Candidate) for the NANOMED European Training Network

within the Marie Sklodowska Curie Programme (1,0 fte)

Application deadline: 18 November 2015 (Closed)

Responsibilities

The core activity of the Pharmaceutics groups is the design and pre-clinical testing of tailor-made drug delivery systems for site-specific, time- and/or rate-controlled delivery of small molecular weight drugs, therapeutic proteins, and nucleic acids (including DNA and siRNA). The major strength of the department is the multidisciplinary nature. As such it can cover the development of drug delivery systems from the design and synthesis up to preclinical testing. It has a good infrastructure for synthesis and characterization of nanoparticles in addition to a dedicated cell culture facility. In addition, it has access to one of the biggest laboratory animal facilities in Europe providing support in animal testing and in vivo imaging. The dept. Pharmaceutics is a member of the faculty of Science, but is also part of the Utrecht Life Science Cluster with the aim to advance therapies into the clinic. In addition, the dept. Pharmaceutics has many collaborations with academic groups and biopharmaceutical companies worldwide.

The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. You will be enrolled in the Graduate School of Life Sciences of Utrecht University and will defend your PhD at the end of the project. The PhD research in the Netherlands will be conducted in English.

Early Stage Researcher 6: Self-assembling peptides as vaccine delivery systems

The task of the ESR is to rationally design molecularly-defined supramolecular cancer vaccines using amphiphilic self-assembling peptides as scaffolds. These cancer vaccines will be designed to carry tumor-specific peptide epitopes in addition to immune activating nucleic acids. The supramolecular structure of these peptide vesicles will be scrutinized using advanced analytical techniques including dynamic and static light scattering and solid state NMR. The capacity of these nanocarriers to deliver tumor antigens to antien presenting cells and to evoke a protective immune responses will be evaluated bot in vitro and in vivo.

Skills required: recombinant peptide production in E. coli, supramolecular chemistry, NMR analysis, nanoscience; affinity with life sciences research, in particular immunology.

Work environment

You will perform your PhD research in a multidisciplinary Initial Training Network (ITN) project called NANOMED.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree; You have excellent communication skills and are able to work efficiently in a team. Specific technical requirements are mentioned separately for the individual ESR descriptions. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in the Netherlands for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays such as holidays are not taken into account).

What we have to offer

  • employment: 1,0 fte;
  • the gross starting salary amounts to € 2,125 per month, and will increase to € 2,717 in the fourth year;
  • in addition to the salary: an 8 % holiday allowance and an 8.3 % end-of-year bonus;
  • duration of the contract: 4 years;
  • you will be classified as a PhD candidate in the Dutch university job-ranking system (UFO).

Are you interested in our excellent employment conditions?

Would you like to know more?

Are you interested?

You should upload your application exclusively using the button ‘Apply’ on the relevant vacancy on the UU vacancy website. Your application should include (and be limited to) the following attachments:

  • Letter of motivation
  • Curriculum Vitae

For more information on your application: +31 (0)6 22736567.

No commercial propositions please.

ESR5: (POSITION FILLED) Hybrid protein-based micelles; University of Bordeaux (France)

The University of Bordeaux (UB) is a multidisciplinary University counting about 45.000 students and 5630 staff. UB offers 245 curricula leading to national degrees and about 35 international master and doctorate programs. Over the past 15 years, UB has been actively contributing to the strengthening of the European and Higher Education and Research Areas by welcoming more than 6200 foreign students and developing an extensive network of more than 200 partners.

The University of Bordeaux is engaged in challenging programs towards scientific excellence and societal perspectives. The Department of Science and Technology is located in a green and renewed campus with state-of-the-art facilities.

Early Stage Researcher (PhD Candidate) for the NANOMED European Training Network

within the Marie Sklodowska Curie Programme (1,0 fte)

Application deadline: 18 November 2015 

Responsibilities

The “Laboratoire de Chimie des Polymères Organiques” (LCPO) is a joint research unit of the Bordeaux University, the CNRS and the Bordeaux National Polytechnic Institute. With 150 persons, LCPO focuses its researches on the development of new functional polymers for targeted applications in various fields, like sustainable development, life science and energy. The group « Polymer Self-Assembly and Life Sciences » leaded by Prof. S. Lecommandoux is a very international and multidisciplinary group of about 25 persons, focusing on challenging and innovative research such as (1) the design of polypeptide and polysaccharide based block copolymer assemblies, mainly polymersomes, for smart drug delivery purposes; (2) the design of complex self-assembled nanostructures mimicking viruses or cells; (3) the development of polymer and hybrid nanoparticles formulations, including inorganic nanoparticles for theranostics (solvent displacement, double emulsion, microfluidics). In addition, Lecommandoux’s lab has many collaborations with academic groups and biopharmaceutical companies worldwide.

The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. You will be enrolled in the Doctoral School of Chemistry of the University of Bordeaux and will defend your PhD at the end of the project. The PhD research will be conducted in English.

Early Stage Researcher 5: Hybrid protein-based micelles

In this ESR project, a series of Elastin-Like Proteins (ELPs) functional copolymers will be designed and prepared. These original copolymers have a LCST that can be modulated to control the self-assembly process. In addition, specific functional methionine groups can be introduced, allowing efficient and selective grafting of hydrophobic side groups (cholesterol, aliphatic) or hydrophilic functional biomolecules, such targeting peptides. The ability of such nanosystems to load and release drugs, and internalize cells specifically will be evaluated.

Skills required: polymer chemistry, nanoscience, protein engineering.

Work environment

You will perform your PhD research in a multidisciplinary Initial Training Network (ITN) project called NANOMED.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree; You have excellent communication skills and are able to work efficiently in a team. Specific technical requirements are mentioned separately for the individual ESR descriptions. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in France for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays such as holidays are not taken into account).

What we have to offer

  • employment: 1,0 fte;
  • the average gross salary is € 2,854 per month;
  • duration of the contract: 3 years;

Would you like to know more?

  • Further information on: The NANOMED project
  • Further information on: LCPO
  • For more information about this vacancy, please contact:
    • Prof. Dr. Sebastien Lecommandoux (lecommandoux@enscbp.fr)

Are you interested?

Please send your application to Prof. Lecommandoux (lecommandoux@enscbp.fr). Your application should include (and be limited to) the following attachments:

  • Letter of motivation
  • Curriculum Vitae

For more information on your application: +33 5 40 00 22 41.

No commercial proposition please.

ESR4: (POSITION FILLED) Polypeptide-based polymersomes; University of Bordeaux (France)

The University of Bordeaux (UB) is a multidisciplinary University counting about 45.000 students and 5630 staff. UB offers 245 curricula leading to national degrees and about 35 international master and doctorate programs. Over the past 15 years, UB has been actively contributing to the strengthening of the European and Higher Education and Research Areas by welcoming more than 6200 foreign students and developing an extensive network of more than 200 partners.

The University of Bordeaux is engaged in challenging programs towards scientific excellence and societal perspectives. The Department of Science and Technology is located in a green and renewed campus with state-of-the-art facilities.

Early Stage Researcher (PhD Candidate) for the NANOMED European Training Network

within the Marie Sklodowska Curie Programme (1,0 fte)

Application deadline: 18 November 2015

Responsibilities

The “Laboratoire de Chimie des Polymères Organiques” (LCPO) is a joint research unit of the Bordeaux University, the CNRS and the Bordeaux National Polytechnic Institute. With 150 persons, LCPO focuses its researches on the development of new functional polymers for targeted applications in various fields, like sustainable development, life science and energy. The group « Polymer Self-Assembly and Life Sciences » leaded by Prof. S. Lecommandoux is a very international and multidisciplinary group of about 25 persons, focusing on challenging and innovative research such as (1) the design of polypeptide and polysaccharide based block copolymer assemblies, mainly polymersomes, for smart drug delivery purposes; (2) the design of complex self-assembled nanostructures mimicking viruses or cells; (3) the development of polymer and hybrid nanoparticles formulations, including inorganic nanoparticles for theranostics (solvent displacement, double emulsion, microfluidics). In addition, Lecommandoux’s lab has many collaborations with academic groups and biopharmaceutical companies worldwide.

The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. You will be enrolled in the Doctoral School of Chemistry of the University of Bordeaux and will defend your PhD at the end of the project. The PhD research will be conducted in English.

Early Stage Researcher 4: Polypeptide-based polymersomes

The task of the ESR is to develop a reproducible and scalable strategy for the design of polypeptide-based polymersomes based polypeptides. Especially, poly(glutamic acid)-based polymersomes will be first synthesized using ring opening polymerization methods. In parallel, the biocompatible but biologically inert poly(glutamate) will be replaced by a hydrophilic and bioactive peptide segment in order to construct in a one-step approach surface-active polymersomes (metallo-protease sensitive and/or targeting peptide). Polymersome formulation, loading and release, and its scalability will be also tested using microfluid devices.

Skills required: polymer chemistry and physical chemistry, nanoscience, colloidal science.

Work environment

You will perform your PhD research in a multidisciplinary Initial Training Network (ITN) project called NANOMED.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree; You have excellent communication skills and are able to work efficiently in a team. Specific technical requirements are mentioned separately for the individual ESR descriptions. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in France for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays such as holidays are not taken into account).

What we have to offer

  • employment: 1,0 fte;
  • the average gross salary is € 2,854 per month;
  • duration of the contract: 3 years;

Would you like to know more?

  • Further information on: The NANOMED project
  • Further information on: LCPO
  • For more information about this vacancy, please contact:
    • Prof. Dr. Sebastien Lecommandoux (lecommandoux@enscbp.fr)

Are you interested?

Please send your application to Prof. Lecommandoux (lecommandoux@enscbp.fr). Your application should include (and be limited to) the following attachments:

  • Letter of motivation
  • Curriculum Vitae

For more information on your application: +33 5 40 00 22 41.

No commercial proposition please.

ESR3: (POSITION FILLED) Particle shape effects; Radboud University (Nijmegen, The Netherlands)

At Radboud University, we perform research and educate students covering the full width of the academic spectrum. Our university is located on a green, modern campus with state-of-the-art facilities. The atmosphere on campus is open and personal, which stimulates colleagues to share their knowledge beyond the boundaries of their own discipline. It encourages all to look further, to see more. Thus, Radboud University contributes to the development of new perspectives, within science and within society. This makes Radboud University successful and of international importance.

Early Stage Researcher (PhD Candidate) for the NANOMED European Training Network

within the Marie Sklodowska Curie Programme (1,0 fte)

Application deadline: CLOSED

Responsibilities

Prof. Jan van Hest’s research group at Radboud University, Faculty of Science, Nijmegen in the Netherlands, offers a programme of training in the field of Bio-Organic Chemistry. The group’s target is to create bio-inspired materials and processes in order to combine the functionality of biological systems with the flexibility and robustness of synthetic structures, using a variety of synthetic techniques, such as protein engineering, peptide synthesis and controlled polymerization methods.  The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. You will be enrolled in Radboud University’s doctoral programme and will defend your PhD at the end of the project. The PhD research in the Netherlands will be conducted in English.

Early Stage Researcher 3: Particle shape effects

The objective of this ESR project is to establish the effect polymersome shape has on cell uptake and drug release. Different shapes lead to different interaction surfaces between cells and particles. This will affect cell uptake and particle biodistribution.

Particles with disc like and oblate shapes will be produced via dialysis-induced osmotic pressure; tubular polymersomes will be obtained via fast membrane cross-linking. All particles are composed of biodegrdable block copolymers. The effect of shape on drug delvery will be investigated.

Skills required: polymer chemistry, supramolecular chemistry, nanoscience; affinity with life sciences research.

Work environment

You will perform your PhD research in a multidisciplinary Initial Training Network (ITN) project called NANOMED.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree; You have excellent communication skills and are able to work efficiently in a team. Specific technical requirements are mentioned separately for the individual ESR descriptions. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in the Netherlands for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays such as holidays are not taken into account).

What we have to offer

  • employment: 1,0 fte;
  • the gross starting salary amounts to € 2,125 per month, and will increase to € 2,717 in the fourth year;
  • in addition to the salary: an 8 % holiday allowance and an 8.3 % end-of-year bonus;
  • duration of the contract: 4 years;
  • you will be classified as a PhD candidate in the Dutch university job-ranking system (UFO).

Are you interested in our excellent employment conditions?

Would you like to know more?

Are you interested?

You should upload your application (attn. of Ms. W. van der Pluijm) exclusively using the button ‘Apply’ on the RU vacancy website. Your application should include (and be limited to) the following attachments:

  • Letter of motivation
  • Curriculum Vitae

For more information on your application: +31 24 3652131.

No commercial propositions please.

ESR2: (POSITION FILLED) Polymer micelles based on elastin-like polypeptides; Radboud University (Nijmegen, The Netherlands)

At Radboud University, we perform research and educate students covering the full width of the academic spectrum. Our university is located on a green, modern campus with state-of-the-art facilities. The atmosphere on campus is open and personal, which stimulates colleagues to share their knowledge beyond the boundaries of their own discipline. It encourages all to look further, to see more. Thus, Radboud University contributes to the development of new perspectives, within science and within society. This makes Radboud University successful and of international importance.

Early Stage Researcher (PhD Candidate) for the NANOMED European Training Network

within the Marie Sklodowska Curie Programme (1,0 fte)

Application deadline: CLOSED

Responsibilities

Prof. Jan van Hest’s research group at Radboud University, Faculty of Science, Nijmegen in the Netherlands, offers a programme of training in the field of Bio-Organic Chemistry. The group’s target is to create bio-inspired materials and processes in order to combine the functionality of biological systems with the flexibility and robustness of synthetic structures, using a variety of synthetic techniques, such as protein engineering, peptide synthesis and controlled polymerization methods.  The NANOMED project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. You will be enrolled in Radboud University’s doctoral programme and will defend your PhD at the end of the project. The PhD research in the Netherlands will be conducted in English.

Early Stage Researcher 2: Polymer micelles based on elastin-like polypeptides

In this task, a protein engineering approach will be followed to construct a series of Elastin-Like Ppolypeptide (ELP) block copolymers, which will assemble into polymer micelles. High cell density fermentation will be employed to improve the availability of the ELP particles. The ELP micelles will be stabilized and decorated with targeting motifs to make directed drug delivery possible. Release of conjugated (hydrophobic) drugs will be achieved by the usage of hydrolytically sensitive linkers.

Skills required: protein engineering, nanoscience, bioconjugation chemistry; affinity with life sciences research.

Work environment

You will perform your PhD research in a multidisciplinary Initial Training Network (ITN) project called NANOMED.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree; You have excellent communication skills and are able to work efficiently in a team. Specific technical requirements are mentioned separately for the individual ESR descriptions. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in the Netherlands for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays such as holidays are not taken into account).

What we have to offer

  • employment: 1,0 fte;
  • the gross starting salary amounts to € 2,125 per month, and will increase to € 2,717 in the fourth year;
  • in addition to the salary: an 8 % holiday allowance and an 8.3 % end-of-year bonus;
  • duration of the contract: 4 years;
  • you will be classified as a PhD candidate in the Dutch university job-ranking system (UFO).

Are you interested in our excellent employment conditions?

Would you like to know more?

Are you interested?

You should upload your application (attn. of Ms. W. van der Pluijm) exclusively using the button ‘Apply’ on the RU vacancy website. Your application should include (and be limited to) the following attachments:

  • Letter of motivation
  • Curriculum Vitae

For more information on your application: +31 24 3652131.

No commercial propositions please.