ESR 03 : Roxane Ridolfo

Born and raised in France, Roxane has developed a passion for nanomedicine. Before graduating in 2016 with a MSc in Chemistry and Physics with a speciality in polymers and formulation from Ecole Nationale Supérieure de Chimie, Biologie et Physique de Bordeaux (Pessac, France), Roxane did two internships working on drug delivery systems. First, she worked in the Pr. Vincent Rotello’s group at UMASS (Amherst, Massachusetts, USA), where she developed polymer-based nanospheres for delivery applications (cancer therapy and biofilm treatment). Then, she joined the Pr. Jan van Hest’s group at the Radboud University (Nijmegen, The Netherlands), where she worked on biodegradable polymer-based micelles formulation and characterization for drug delivery to treat leukemia.

Nowadays, Roxane is a 2nd year-PhD student at TU/e (Eindhoven, The Netherlands), linked to Pr. Jan van Hest’s group. Her project is called Particle Shape Effect and takes part of the European framework NANOMED.


Project topic: Particle Shape Effect (ESR3)

The objective of this project is to establish the effect micelle and polymersome shape has on drug release and cell uptake. Different shapes lead to different interaction surfaces between cells and particles. This will affect cell uptake and particle biodistribution.

A focus will be made on retinal drug delivery. All particles are composed of biodegradable block copolymers and the degradation behavior will be investigated.

Home country:
France
NanoMed partner:
TU/e
Supervisor:
Jan van Hest
Starting date:
September 9th, 2016
Publications:
  • David S. Williams, Imke A.B. Pijpers, Roxane Ridolfo, Jan C.M. van Hest, Controlling the morphology of copolymeric vectors for next generation nanomedicine, J Control Release. 259 (2017) 29–39 DOI
  • Roxane Ridolfo, Benjamin C. Ede, Paraskevi Diamanti, Paul B. White, Adam Perriman, Jan C. M. van Hest, Allison Blair, David S. Williams, Drug loaded nanovectors via direct hydration as a new platform for cancer therapeutics, Small Nanomedicine 1703774 (2018) DOI
LinkedIn profile
Meetings:
  • July 2016, NanoMed kick-off meeting
  • February 2017, NanoMed meeting, Imperial College of London
  • March 2017, Dutch Polymer Days, Lunteren, Netherlands
  • September 2017, NanoMed meeting, Ghent University, Belgium
  • September 2017, f-TALES ‘Nanomaterials in Biomedical Sciences’ conference, Ghent, Belgium
  • December 2017, SFNano 4th annual meeting, Bordeaux, France
  • December 2017, NanoMed midterm review, TU/e Eindhoven, Netherlands
  • April 2018, NanoMed and Ocuther joint meeting, Egmond Aan Zee, Netherlands
  • April 2018, 5th edition of the European Symposium on Controlled Drug Delivery, Egmond Aan Zee, Netherlands
  • April 2018, 18th Dutch Polymer Days conference, AWARD winner best oral presentation biomedical workshop, Lunteren, Netherlands best oral presentation biomedical workshop, Lunteren, Netherlands
Secondments:

Performed:

  • September/November 2017, Bristol University, UK: cell experiments
  • May/June 2018, Faculty of Pharmacy, University of Helsinki, with ESR12 and ESR13: Drug encapsulation and release studies, Nanoparticle mobility experiments in ex-vivo porcine eye

Planned:

  • October/November 2018, Imperial College of London
  • May/June 2019, Faculty of Pharmacy, University of Helsinki

Welcomed at TU/e Eindhoven:

  • November/December 2016, ESR13: polymer synthesis and nanoparticle formulation
  • March/April 2018, ESR13: polymer synthesis and nanoparticle formulation + characterizations
  • April 2018, ESR4 : formulation and characterization of nanoparticles