ESR 07 : Mahsa Bagheri

Mahsa obtained her PharmD degree from Mashhad University of Medical Sciences in 2013. She was always interested in pharmaceutical formulations and drug delivery systems and thus her PharmD project was In vitro and In vivo study of TAT modified liposomal doxorubicin in colon carcinoma model. Then she worked as a hospital pharmacist in a cardiovascular center for two years as her compulsory medical service where she became interested in drug-eluting stents as platforms for sustain drug delivery. Since 2016 she joined Utrecht University department of pharmaceutical sciences to start her PhD study. She is currently working on preparation of small-sized polymeric micelles for targeted drug delivery. She will later investigate the efficacy of this well-defined polymeric micelles in tumor cell lines as well as suitable animal model.


Project topic: Small-sized polymeric micelles for target drug delivery

 

This project involves the following:

  1. Preparation of variety of well-defined p(HPMA-Bz)-PEG block copolymers synthesized by a well-defined macroinitiator via controlled radical polymerization methods.
  2. Evaluation of the effects of formulation characteristics and processing conditions on the size of the formed polymeric micelles
  3. Using microfluidics technique to prepare well defined micelles with high loading capacity.
  4. Preparation of the active targeted drug delivery systems using ligands such as folic acid or nanobody specific for the EGFR receptor to render the micelles cell specific property.
  5. In vitro evaluation of targeted and non-targeted polymeric micelles in 2D and 3D cell (organoids) models; interesting systems will be evaluated in suitable animal models for pK and pD.
  6. Preparation of stimuli-sensitive polymeric micelles by conjugation of pH-sensitive linkers (hydrazone, orthoester) or reduction-sensitive (disulfides) bonds.
  7. Substitution of PEG by e.g. another hydrophilic polymer such as pHPMA in order to further decrease RES mediated uptake, therefore increasing the circulation time.
Home country: Iran
NanoMed partner: Utrecht University
Supervisor: Prof. Wim Hennink, Dr. Rene van Nostrum, Dr. Enrico Mastrobatissta
Starting date: April 1st, 2016
Publications:
  • Azarpazhooh MR, Mobarra N, Parizadeh S M, Tavallaie S, Bagheri M, Rahsepar AA, Ghayour- Mobarhan M, Sahebkar A, Frens GA. (2010). Serum high-sensitivity C-reactive protein and heat shock protein 27 antibody titers in patients with stroke and 6-month prognosis. Angiology. 61(6):607-12.
    Panahi Y, Ghanei M, Vahedi E, Ghazvini A, Parvin S, Madanchi N, Bagheri M, Sahebkar A.
  • Effect of recombinant human IFNg in the treatment of chronic pulmonary complications due to sulfur mustard intoxication. Journal of Immunotoxicology. DOI: 10.3109/1547691X.2013.797525.
  • Bagheri M, Mohammadi M, Ramezani M. (2016). Nanomaterial coatings applied on stent surfaces. Nanomedicine. 11(10):1309-1326.
Meetings:
  • July 2016 Nanomed kick-off meeting
Secondments:
  • University of Bordeaux
  • Ghent University
  • ChemConnection