ESR 11 : Conor Horgan

I am currently conducting my PhD studies in Prof. Molly Stevens’ group at Imperial College London. I am working on the development of a multi-spectroscopic system to enable the in vivo detection and activation of nanomedicine formulations for cancer diagnosis and treatment. Previously I completed degrees in biomedical engineering and computer science in Australia, focusing on the development and characterisation of novel biological systems for application to tissue engineering, regenerative medicine, and biosensing. I am particularly interested in the development of novel materials and systems designed for rapid and effective clinical translation. As such, I enjoy working at the interface of materials, biology, and characterisation techniques, using my multidisciplinary background to tackle medical problems from multiple angles.


Project topic: Raman Spectroscopy and Photodynamic Therapy for Cancer Theranostics

 

I am working on the development of a multi-spectroscopy system that combines Raman spectroscopy and photodynamic therapy. This system will enable in vivo detection of cancerous tissues and Raman-active nanoformulations, which can then be activated to achieve spatially and temporally localised release of chemotherapeutic agents.

Home country: Australia

 

NanoMed partner: Imperial College London

 

Supervisor: Professor Molly Stevens

 

Starting date: May 3rd, 2016

 

Publications:
  • Horgan, C., Rodriguez, A., Bruggeman, K., Li, R., Raynes, J., Day, L., White, J., Williams, R., Nisbet, D., Characterisation of minimalist co-assembled fmoc self-assembling peptide systems for presentation of multiple bioactive epitopes. Acta Biomaterialia, 2016, 38: p. 11-22
    Horgan, C., Rapson, T., Jackson, C., Sutherland, T., Phosphorescent oxygen-sensing and singlet oxygen production by a biosynthetic silk. RSC Advances, 2016. 6: p. 39530-39533
  • Li, R., Horgan, C., Long, B., Rodriguez, A., Mather, L., Barrow, C., Nisbet, D., Williams, R., Tuning the mechanical and morphological properties of self-assembled peptide hydrogels via control over the gelation mechanism through regulation of ionic strength and the rate of pH change. RSC Advances, 2015, 5(1): p. 301-307
  • Rodriguez, A., Wang, T., Bruggeman, K., Horgan, C., Li, R., Williams, R., Parish, C., Nisbet, D., In vivo assessment of grafted cortical neural progenitor cells and host response to functionalized self-assembling peptide hydrogels and implications for tissue repair. Journal of Materials Chemistry B, 2014. 2(44): p. 7771-7778
Meetings:
  • 2016 – Nanomed Meeting (Nijmegen, The Netherlands)
  • 2015 – Australasian Society for Biomaterials and Tissue Engineering (Sydney, Australia)
  • 2014 – Australasian Society for Biomaterials and Tissue Engineering (Melbourne, Australia)
  • 2014 – Australasian Conference of Undergraduate Research (Canberra, Australia)
Secondments:
  • University of Helsinki
  • University of Ghent
  • Polyvation