ESR 14 : Mike Wels


Mike has obtained a Master’s degree in Pharmaceutical Sciences by completing the program Drug Innovation at Utrecht University, The Netherlands. During his Master’s he finished an internship at Utrecht University with a thesis titled: “Preparation and characterization of a lysolipid-based thermosensitive liposomal formulation for methotrexate” and an internship at Ghent University with a thesis called “Intravitreal delivery of mRNA targeted towards Müller cells using lipid-based nanoparticles”.

Project topic: Nanoformulations for siRNA delivery

Small interfering RNAs (siRNAs) are a promising solution in downregulating the expression of specific genes. However, this is not without difficulties as the siRNA has to overcome many extra-and intracellular obstacles to allow functional delivery in the cytoplasm of target cells. This project focuses on improving siRNA delivery by encapsulating it in polysaccharide nanogel formulations and promoting its cellular delivery efficiency through the addition of small molecule adjuvants.

The formulations will be evaluated for intraperitoneal and ocular applications, applying appropriate in vitro, ex vivo and in vivo models.

Home country: The Netherlands
NanoMed partner: Ghent
Supervisor: Prof. Koen Raemdonck and Prof. Stefaan de Smedt
Starting date: January 1st, 2018
Publications:
Meetings:
  • December 2018 – NanoMed Midterm Review meeting
  • April 2018 – Nanomed meeting
  • April 2018 – ESCDD
Secondments:
  • Utrecht University (planned for 2nd half of 2018)