ESR 15 : Jaleesa Bresseleers

Jaleesa Bresseleers received her M.Sc. in Molecular Life Sciences from Radboud University in 2013. During her master’s she worked on both capsid protein nanoparticles for the creation of nanoreactors in the Bio-Organic Chemistry group of Prof. Jan van Hest at Radboud University; and protein hydrogels for the development of a stress sensor in the chemical engineering group of Prof. David Tirrell at California Institute of Technology. Currently she is a Ph.D. candidate working on the GMP production of nanomedicines in at ChemConnection under the supervision of Dr. Silvie Meeuwissen and Prof. Jan van Hest.


Project topic: Development of scalable processes for the manufacture of nanomedicines.

 

The aim of this PhD project is to prepare robust and scalable manufacturing processes for the production of biodegradable nanomedicines and their building blocks. To achieve this, both batch and continuous flow processes will be developed and evaluated for the manufacture of highly potent materials. The development of these nanomedicines not only entails their preparation but also includes purification, reduction of production costs and the implementation of analytical methods to characterize the products. The main idea is to develop scalable routes towards a final nanomedicine product which is then tested for appropriate drug release, biodegradation and toxicology. Also investigation regarding shelf life, regulatory issues and safety issues will eventually readily translate into the GMP manufacturing of a clinical product.

Home country: Belgium

 

NanoMed partner: ChemConnection and TU Eindhoven

 

Supervisor: Dr. Silvie Meeuwissen and Prof. Jan van Hest

 

Starting date: June 1st, 2016

 

Publications:
Meetings:
  • July 2016 Nanomed kick-off meeting
Secondments:
  • University of Utrecht
  • Ghent University
  • University of Bordeaux