ESR 09 : Molood Shariati



Bachelor’s degree : Cellular & Molecular Biology- Genetics

Master’s degree student in Cellular and Molecular Biology-Genetics at Tarbiat Modares University. Tehran, Iran
(Master thesis entitled : Investigation of Dendrosomal Curcumin inhibitory effect on the Human Telomerase Reverse Transcriptase gene ( hTERT ) promoter through induction of TGFβ1 signaling pathway in hepatocarcinoma cell line (Huh7) )

Research interests:

Nanomedicine, nanoparticle-based drug delivery systems, Anti-cancer Agents, Chemotherapeutics

Project topic: Evaluating the potential of different nanomaterials for IP administration of chemotherapeutics and nucleic acids

In recent years, intraperitoneal (IP) chemotherapy has been receiving recognition as an encouraging post-surgical treatment of peritoneal carcinomatosis (PC). Compared to IV chemotherapy, this treatment modality benefits from higher concentration of anticancer drugs in the peritoneal cavity, along with reduced systemic toxicity. However, rapid leakage of chemotherapeutics from abdominal cavity to systemic circulation has remained as the chief drawback regarding IP drug delivery. Consequently, we aimed at taking advantage of nanostructured pharmaceutical carriers to enhance the local retention of anticancer drugs and nucleic acids subsequent to IP perfusion.

Home country: Iran
NanoMed partner: Ghent University
Supervisor: Katrien Remaut, Stefaan De Smedt
Starting date: March 30th, 2016
  • July 2016 Nanomed kick-off meeting
  • Imperial College
  • Utrecht University
  • ChemConnection